One of the adverse side effects of retinol is the flaking and dryness that come with it, which can occur with retinol virgins and experienced, multi-year users. But applying moisturizer can help majorly. “Layering retinol in between two layers of moisturizer can reduce redness, sensitivity, peeling, flaking, and dryness that is often associated with vitamin A,” explains Dr. Elizabeth Houshmand, a board-certified dermatologist in Dallas, TX. That’s because the moisturizer acts as a buffer of sorts to prevent and diminish the potential for redness, irritations, sensitivities, dryness, and peeling. Plus, using moisturizer in tandem with retinol helps the skin to function optimally so that the retinol can penetrate as designed and work towards optimal results.