Read more to clarify the symbiotic relationship between these skincare superstars.

Single-ingredient products, while effective, often yield even better results when combined.

The trick is knowing which ingredient pairings target your skin goals when there are so many options at your fingertips.

VITAMIN C AND COLLAGEN

“Vitamin C acts as a glue that binds collagen fibers together, and this duo plumps, tightens, and [vitamin C] brightens like magic,” says celebrity aesthetician Natalie Aguilar.

CERAMIDES AND RETINOL

Retinol has anti-aging and anti-acne benefits, and ceramides helps to counteract the dryness and irritation that can accompany retinoid use. Together, they’re magic.

POLYGLUTAMIC ACID AND HYALURONIC ACID

“Polyglutamic acid is thought to inhibit the natural breakdown of hyaluronic acid by blocking hyaluronidase, leading to synergistic results, boosting moisture and plumping the skin to improve fine lines,” says Marisa Garshick, M.D.

LACTIC ACID AND RETINOL

These AHAs “can make each ingredient even more efficacious to treat skin that looks dull, crinkly, sun damaged — or sudden acne breakouts,” says Aguilar.

RETINOL AND HYALURONIC ACID

Nicole Frontera, a nurse practitioner, recommends applying hydrating HA to counteract the dry, flakiness retinol use can sometimes cause.

VITAMINC C AND E, PLUS FERULIC ACID

“When ferulic acid is combined with other antioxidants such as vitamin C and E, it has been shown to boost stability and effectiveness,” says Dr. Garshick.

NIACINAMIDE AND SALICYLIC ACID

“These work together to help control sebum, improve the overall appearance of pores as well as the general texture of the skin,” says Dr. Garshick.